![]() ![]() The importance of the ratio, VA/QC, in pulmonary gas exchange did not appear in this paper de novo but emerged in two papers, published by physiologists in 19, concerned with the volume of the respiratory dead space. ![]() The concept was first suggested in a paper published in the 1918/1919 volume of The Journal of Physiology to account for the crippling breathlessness suffered by the soldiers who had survived gas attacks in the First World War. Large differences in the ratio of alveolar ventilation to alveolar capillary blood flow, VA/QC, in different regions of the lungs have been recognised as a principal cause of hypoxaemia in respiratory disease since the 1950s. The Physiological Society’s blue plaquesĪlveolar ventilation-perfusion ratios and pulmonary gas exchange: 100 years since recognition A debate about physiological measurement provides insight into a practical problemĭepartment of Bioengineering, Imperial College London, UKĬC Michel, Department of Bioengineering, Imperial College London, UK. ![]()
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